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GA, FL, AL: Dilantin and SJS and Purple Glove Syndrome : Trial ...

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According to a quarterly report issued in late 2008, the FDA investigated  occurrences where  Dilantin (phenytoin) injections led to a disorder known Purple Glove Syndrome. This condition -named after the discoloration that  often accompanies it, can lead to the need for emergency surgery, and even limb amputation, if it becomes serious. Phenytoin has been administered intravenously since 1956.  But occasionally, this treatment can lead to a complication called Purple Glove Syndrome.  Purple Glove Syndrome starts as a  pale blue or dark purple discoloration which appears around the intravenous insertion site 2  to 12 hours after the administration of the drug. Progression occurs during the next 12 to 16 hours as developing edema and continued discoloration spread around all sides of  the affected limb. If a patient is fortunate, the discoloration and edema will gradually fade, and the affected limb will heal within 2 to 4 weeks.  However, Purple Glove Syndrome can sometimes turn quite serious, resulting in the death of affected tissue. When such necrosis occurs, a patient may require surgery to restore blood flow to the affected tissue.  The most severe cases of Purple Glove Syndrome can lead to amputation of the injured limb. In its report, the FDA did not say how many cases of phenytoin-related Purple Glove Syndrome it was investigating.  But a 1998 study conducted by researchers at the Mayo Clinic found that of 152 patients receiving intravenous Dilantin (phenytoin), 9  (about 5.9%) developed Purple Glove Syndrome.  The study also found that the disorder was more likely to affect the elderly, and people who received more than one dose of phenytoin. No one yet understands why intravenous Dilantin can cause Purple Glove Syndrome.  The disorder does occur when Dilantin - which has highly alkaline PH - leaks into the interstitial tissue.  But Purple Glove Syndrome is also seen in patients were such phenytoin leakage has not occurred.  Some health practitioners believe this could have something to do with the exact formulation of the phenytoin injection.

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Dilantin (Phenytoin)

A pharmacist explains how Dilantin works, why doctors prescribe this anticonvulsant, and common side effects of the drug.Watch More Health Videos ...

Dilantin - News


CA orders Mercury Drug to pay couple P100,000 for wrong medicine
Canyanay Avenue in Parañaque City gave the Garcia couple anti-convulsion drug Dilantin in 1999, according to a 13-page decision by the CA's 17th Division.

"SJS Made Me Feel Like a Bubble Boy"
"SJS Made Me Feel Like a Bubble Boy" Clarkesville, TN: Daniel, 22, was only six months old when he was given Dilantin, an anti-epileptic medication used to control seizures.

Why is my father suffering from recurrent seizures?
The doctor stated that they are the post operative changes and has changed the medicine from Eptoin to Dilantin. Why is my father suffering from recurrent

Side effects of Felodipine
You should discuss with your doctor whether felodipine can be taken if you are already taking erythromycin antibiotics, Dilantin, Vantac,

Abbott's PROGRESS Study of Kaletra and Isentress Compared with a Standard HIV ...
Kaletra should not be administered once daily in combination with carbamazepine (Tegretol® and Epitol®), phenobarbital (Luminal®), or phenytoin (Dilantin®).

Marian Salzman: Headstrong, Part II: The Creative Process
I became addicted to bulletin boards and sought advice from all corners: Anyone else allergic to Dilantin? Suffer from sheer exhaustion and sleeplessness

WHITEHEAD v. UNITED PARCEL SERVICE, INC.
Whitehead answered yes, and explained he took Dilantin to treat it. He has been seizure free for more than a decade. The doctor completed the physical and

Anti Depressants Directory

Phenytoin - Wikipedia, the free encyclopedia
Dilantin made an appearance in the 1962 novel One Flew Over the Cuckoo's Nest by Ken Kesey, both as an anticonvulsant and as a mechanism to control inmate behavior. ...

Dilantin (Phenytoin) Drug Information: Uses, Side Effects ...
Learn about the prescription medication Dilantin (Phenytoin), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.

Dilantin Information from Drugs.com
Dilantin (phenytoin) is an anti-epileptic drug used to control seizures. Includes Dilantin side effects, interactions and indications.

INFATABS® Dilantin® (Phenytoin Tablets, USP)
Dilantin (phenytoin) is related to the barbiturates in chemical ... Dilantin Infatabs (Phenytoin Tablets, USP) are indicated for the control of generalized ...

Dilantin Oral : Uses, Side Effects, Interactions, Pictures ...
Find patient medical information for Dilantin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings

Deciphering the puzzle of his brain: Metro-east man suffered seizures for ...

"She realized that I just plain lost it and wasn't with the program anymore."

Peggy tried talking to him, but he couldn't respond. She put her foot on the brake.

"She said, 'You didn't say anything about this.' (I told her) I didn't want that to be the reason we didn't get along. Eventually, I was going to tell her, but I hoped I wouldn't have to.

"I didn't know if I'd just ruined everything, but she accepted it. I should be thankful for that."

And much more.

They married in , moved into his family home in Belleville and reared three sons, now in their 20s.

"I was their parent, but they were going to have to be mine and keep an eye on me," he said. "You can sense it. All you have to do is stare and they ask you if you're OK."

Ed, a government accountant, umpired baseball during the summer. And took the family on trips around the country to visit all 30 Major League baseball stadiums.

About 10 years ago, Ed and Peggy were sitting on the couch when they got a call from his mother-in-law, Clara Hug.

Suffolk County Police Ask Public For Help In Identifying Body Found on Plum ...

In January, I wrote a blog post about the body of a man that had washed up onto Plum Island's beach . After conducting a post-mortem examination of the body, investigators found that the man had a head injury in the past that had healed well, and there were indications that the man had had prior neurosurgery. He had been taking Dilantin and Phenobarbital, drugs commonly used to control epileptic seizures.

The body was that of an African American male, 5'10" and weighing between 160-190 pounds. He is thought to be between the ages of 50 and 70.

When the body was found, the man was wearing a light green, three-button shirt with dark green horizontal strips, green cargo pants with buttons inscribed, "God Body Collection," size 10 brown loafers, blue plaid boxer shorts and a belt buckle inscribed, "Stacy Adams."

Detectives now think there is a possibility that the man may have been from Connecticut, Rhode Island or Massachusetts.

If you have any information

UC Study Supports Alternative Anti-Seizure Medication Following Acute Brain Injury


A study by researchers at the University of Cincinnati Neuroscience Institute (UCNI) at University Hospital supports the use of an alternative medication to prevent seizures in patients who have suffered a life-threatening traumatic brain injury or bleeding stroke .

This randomized study supports earlier indications that the anti-seizure medication levetiracetam, marketed as Keppra , was as effective at preventing seizures as the traditional medication, phenytoin, marketed as Dilantin, while producing fewer negative side effects. Patients treated with Keppra also had improved long-term outcomes, the researchers found.

The study will be published in the April 2010 issue of the journal Neurocritical Care ; it appeared online on Nov. 7, 2009.

The study of anti-seizure medications in the neuroscience intensive care unit (NSICU) at UC Health University Hospital is part of a focused, ongoing effort to harness scientific evidence to improve treatments and outcomes