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Alkeran bula do medicamento | Bulas de Medicamentos e Farmácias de ...

by Bula do Remédio

Alkeran poderá ser utilizado no tratamento das seguintes patologias: carcinoma da mama: Alkeran, em monoterapia ou em terapêutica de associação , tem um efeito terapêutico significativo em alguns doentes com carcinoma da mama avançado; policitemia rubra vera: Alkeran mostrou eficácia no tratamento de alguns doentes.

2. ANTES DE TOMAR Alkeran Como tomar Alkeran). Em doentes com mieloma e com lesão renal tem ocorrido aumento significativo, mas temporário, da uremia nas fases iniciais da terapêutica com melfalano . administração recente ou planeada de uma vacina . A imunização através da administração de uma vacina viva pode originar infecção em indivíduos imunocomprometidos, não se recomendando a imunização com vacinas vivas. ácido nalidíxico: a administração de doses elevadas de melfalano por via intravenosa em associação com ácido nalidíxico provocou morte em crianças, devido a inflamação das mucosas do intestino delgado e do cólon, com hemorragia ; ciclosporina: foi descrita insuficiência renal em doentes submetidos a transplante de medula óssea, tratados com doses elevadas de melfalano , por via intravenosa , e subsequentemente tratados com ciclosporina para prevenir a rejeição do transplante.

Gravidez e aleitamento As mulheres em tratamento com Alkeran não devem amamentar.

Condução de veículos e utilização de máquinas

Não foram efectuados estudos para avaliar o efeito de Alkeran sobre a capacidade de conduzir e utilizar máquinas.

3. COMO TOMAR Alkeran

Tomar Alkeran sempre de acordo com...

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Alkeran (Melphalan) Drug Information: Uses, Side Effects, Drug ...

WARNING

ALKERAN (melphalan) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Severe bone marrow suppression with resulting infection or bleeding may occur. Melphalan is leukemogenic in humans.

Melphalan produces chromosomal aberrations in vitro and in vivo and, therefore, should be considered potentially mutagenic in humans.

ALKERAN (melphalan), also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent which is active against selective human neoplastic diseases. It is known chemically as 4-[bis(2-chloroethyl)amino]- L -phenylalanine. The molecular formula is C

Melphalan is the active L-isomer of the compound and was first synthesized in 1953 by Bergel and Stock; the D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.

Melphalan is practically insoluble in water and has a pKa

ALKERAN is supplied as white, film-coated, round, biconvex tablets containing 2 mg melphalan in amber glass bottles with child-resistant closures. One side is engraved with "GX EH3" and the other side is engraved with an "A."

Bottle of 50 (NDC 59572-302-50).

Store in a refrigerator, 2° to 8° C (36° to 46° F). Protect from light.

REFERENCES

1. ONS Clinical Practice Committee. Cancer Chemotherapy Guidelines and Recommendations for Practice. Pittsburgh, PA: Oncology Nursing Society;1999:32-41.

2. Recommendations for the safe handling of parenteral antineoplastic drugs. Washington, DC: Division of Safety, Clinical Center Pharmacy Department and Cancer Nursing Services, National Institutes of Health; 1992. US Dept of Health and Human Services. Public Health Service publication NIH 92-2621.

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Melphalan (specifically Melphalan hydroc… « Cure bytes

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Melphalan (specifically Melphalan hydroc…

Melphalan (specifically Melphalan hydrochloride, sold as trade name Alkeran) is a chemotherapy drug (type of cancer treatment). It is commonly used to treat multiple myeloma, ovarian cancer and occasionally malignant melanoma. See clinical trials of this drug on TrialX – http://bit.ly/dbfLim

Source: Melphalan (specifically Melphalan hydroc… « Cure bytes

Alkeran (Melphalan) Drug Information: Uses, Side Effects ...
Learn about the prescription medication Alkeran (Melphalan), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.

Alkeran Official FDA information, side effects and uses.
Accurate, FDA approved Alkeran information for healthcare professionals and patients - brought to you by Drugs.com.

Alkeran Facts and Comparisons at Drugs.com
All about Alkeran. View complete and up to date Alkeran information - part of the Drugs.com trusted medication database.

Alkeran Oral : Uses, Side Effects, Interactions, Pictures ...
Find patient medical information for Alkeran Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings

Alkeran, Melphalan, L-PAM - Chemotherapy Drugs, Chemo Side ...
Alkeran is a chemotherapy drug used to treat multiple myeloma, ovarian and other cancers. Other names for chemo drug Alkeran are Melphalan, L-PAM, ...